Signature Science, LLC
  • - TX-Austin
  • Austin, TX, USA
  • Full Time

Position Purpose:

Signature Science seeks candidates with an analytical biochemistry background to join our team in support of defense, forensics, and national security projects. The successful candidate will perform research and development on biochemistry and molecular biology projects focused on protein, metabolite, and lipid analysis. The candidate will be based in our Austin, TX headquarters within the CBRNE Sciences Division. The candidate must have the flexibility to balance multiple on-going tasks while operating efficiently with minimal supervision. The candidate must be motivated to contribute in a team environment, collaborate across multiple scientific and technical disciplines, and be excited to develop new skills. Job functions will include mass spectrometric-based metabolomic and proteomic analysis of biological samples, and the processing and review of the resulting data.

Essential Duties and Responsibilities:

• Perform liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods for sample analysis (e.g., metabolomic and proteomic analysis)
• Perform chemical or protein extraction as well as sample preparation and analysis
• Review raw LC-MS/MS data for quality, and process, analyze, and summarize data
• Presents technical results through the drafting of scientific and technical reports and presentation meetings
• Optimize and/or troubleshoot chemical or molecular assays
• Other duties as assigned
• Performance of all job duties is intended to be completed under limited direct supervision of their supervisor

Required Knowledge, Skills & Abilities:

• Experience in liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods
• Experience analyzing large LC-MS/MS raw data
• Experience in the annotation of chemical results from LC-MS/MS instruments
• Ability to plan and explain a sequence of experiments to meet technical objectives
• Ability to manage multiple tasks with competing priorities simultaneously
• Experience and proficiency with Microsoft Outlook, Excel, Word, and Powerpoint
• Excellent written and verbal communication skills
• Ability to work independently and to interact effectively with individuals on multi-disciplinary teams

• Demonstrated research and development experience related to proteomic or metabolomic analysis
• Experience in developing and/or using automated data analysis tools for LC-MS/MS data • Demonstrated peer-reviewed publication and presentation record
• Experience in using Python or R for data processing, analysis, or visualization


Successful candidate must have a Bachelor's degree in Chemistry, Biochemistry or a related scientific discipline with at least 5 years of directly relevant professional experience.

Certificates and Licenses:

None required


Candidate must be willing to and able to complete a successful background screening to obtain and maintain a government security clearance. Candidates with an active security clearance will be given preference.

Supervisory Responsibilities:

No staff supervisory responsibilities will be expected.

Working Conditions/Equipment:

• Ability to sit or stand for long period of time at lab bench.
• Must be able to lift light (e.g., 25 lbs) loads.
• Must be able and willing to travel via commercial airline as needed to attend conferences or business meetings as needed.

The above job description is not intended to be an all-inclusive list of duties and standards of the position. Incumbents will follow any other instructions, and perform any other related duties, as assigned by their supervisor.

This position has been closed and is no longer available.
Signature Science, LLC


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