Signature Science, LLC
  • - VA-Charlottesville
  • VA, USA
  • Full Time

Position Purpose:   

An Informatics is responsible for identifying and resolving program or data issues, preparing annotated computer code, and validating computer programs with a focus on forensics and metagenomics.


Essential Duties and Responsibilities:


  • Develop tools for management, analysis and interpretation of next generation sequencing data
  • Implement and execute data processing workflows and automated analytic pipelines
  • Create standardized summary tables and figures
  • Manage large dataset collections including analytical results and data quality
  • Develop annotated computer code and conduct code reviews and programming validation
  • Conduct workflow benchmarking
  • Identify inconsistencies and initiate resolution of data problems
  • Prepare SOPs, document source code/workflows, and write reports to summarize computational
    requirements, processing status, and customized analysis results as needed.


Required Knowledge, Skills & Abilities:


  • Knowledge of at least one programming language including Python, C/C++, Perl, Bash, or Ruby and knowledge in at least one environment for high-dimensional data analysis such as Python or R is required.
  • Competent in using Linux/Unix operating system command line interface
  • Ability to develop and query relational databases (MySQL or similar)
  • Familiarity with next-generation sequencing data and open-source bioinformatics tools
  • Familiarity with AWS cloud computing is desired
  • Experience with NextFlow, SnakeMake, or similar workflow/pipeline management systems is desired
  • Experience using Version Control software (e.g., Git or similar) to manage programming code
  • Proactive, self-starter
  • Experience using workflows and sprints throughout the development process Ability to manage multiple tasks
  • Ability to work independently, as well as in a team environment
  • Ability to effectively communicate technical concepts, both written and oral




  • PhD in Data Science or related field
  • 7-10 years of experience managing and analyzing large-scale datasets produced sequencing platforms and deliver solutions for managing, visualizing, analyzing, and interpreting genomic data
  • Manipulate and format data to assess data quality and analyze data



Certificates and Licenses:


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This position requires that the candidate be willing and able to complete a successful background screening for a security clearance. Candidates with an active security clearance will receive preference.


Supervisory Responsibilities:


May serve as a task/project lead.


Working Conditions/ Equipment:

  • Ability to work in varying conditions to include: traditional office environments with sedentary extended periods required for code development and testing;



The above job description is not intended to be an all-inclusive list of duties and standards of the position.  Incumbents will follow any other instructions, and perform any other related duties, as assigned by their supervisor.


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